Itai-Itai disease is caused by chronic poisoning of–

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Cadmium. Itai-Itai disease is caused by chronic poisoning of cadmium (cd). Itai-itai disease is the most severe form of chronic Cd poisoning caused by prolonged oral Cd ingestion. Cadmium toxicity occurs when a person breathes in high levels of cadmium from the air, or eats food or drinks water containing high levels of cadmium. The main target organ of Cd toxicity in itai-itai disease is the kidney, where injury is manifested by tubular and glomerular dysfunction. Renal dysfunction causes an insufficiency of active vitamin D, followed by bone injury consisting of a combination of osteomalacia and osteoporosis.

Itai-Itai disease is caused by chronic poisoning of–

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